Is gamma interferon with your social life?

Yesterday, we went out  shopping for a new couch.  Fraser loves trying out beds and couches, especially the big puffy recliner ones. After all, they are just house trampolines aren’t they? He bounces from couch to couch testing them all out for us, occasionally reclining with his sister with a wry smile on his face. After the third store though, the novelty began to wear off, not just with him but with Brian as well. I count on this boredom factor, as it usually means I have a better chance of getting the couch I want because it means we’ll get out of the store quicker 🙂 Anyhoo, Fraser did what he does when he’s had enough, he started saying ‘chipst’.  Obviously, he wanted chips, but he likes to add a ‘t’ on the end for affect.  So we’re wandering around looking at couches and all we hear is ‘chipst, chipst, chipst, chipst’ over and over again.  He counts on us getting annoyed, as the annoyance factor usually means he has a better chance of getting the chips he wants…hey, wait a minute! So couchless, but armed with enough visual information to go on with, we headed for home with a quick stop at the drive through along the way.  I say to my passengers, ‘does anyone else want chipst’?  No reply.  I say it again to which Eloise replies ‘i’ll have lemonade’ to which I say, ‘that’s not what I asked’.  So, I just decide that one small chipst is our only requirement…easy! All of a sudden, Brian pipes up with ‘I wouldn’t mind a burger. Lets go in’.  He NEVER suggests that, so, we go in to the nearest Maccas for some lunch. Fraser and I sit down to wait, while the other two decide they’re going to use some weird machine to order the food. How did it go from one small chipst to this?  So, I decide to just go with flow and grab the paper to see whats going on in the world. I  decide to bypass the horrific reality that is Donald Trumps speech to the world and open up a random page. I look at the article and  realise, we were meant to come to Maccas, this was no accident! The universe had designed this moment just for me.  There, in front of me, on page 19 of the Herald Sun, a safe distance away from Trump, was the following article …

IMMUNE VESSELS IN BRAIN LINK TO AUTISM

Now, anyone who has followed an alternative health/gut/immune lifestyle for their Autistic child knows not only innately but through years of hard work and research that Autism is inextricably linked to the immune system.  The problem has been that mainstream medicine, mainstream science and especially mainstream media, all like to pounce on such inferences and put us whacko’s  back in our places. The big surprise here was two fold: first of all, the information contained in the article was new to me, which is always exciting, and second,  the fact that this was appearing in the Herald Sun!  This is proof  that these ideas that were considered ‘out there’ not so long ago, are thankfully becoming more and more accepted. Maybe now we’ll get somewhere!

So, what did the article say?  Basically, new immune cells that have been discovered in the meninges of the brain, have an effect on social behaviour. Interferon Gamma, is an immune cell  that is produced in response to a virus or bacteria.  As Fraser has a major problem with Strep bacteria changing his behaviour, this was a massive breakthrough for me which helps to complete more of the big Fraser picture.  When they interfered with Interferon Gamma (IFN-gamma) in mice, their social responses completely changed.  No IFN-gamma, no social interaction, they were wall flowers standing on their own.  Switch IFN-gamma back on, and it was mice party time!  For something so seemingly simple, this could have a profound outcome for Autistic individuals and other neurologic disorders.   So what next?  Well of course that meant going back to Google University (like I ever left).  So, I typed in ‘how to raise Interferon Gamma’, and to my delight, something really simple came up. So simple, that I had to laugh out loud.  The good old probiotic, beloved of parents of Autistic children the world over…Lactobacillus GG, aka Culterelle.  I have never been able to find out if this probiotic lowered or raised histamine, so I have and will continue to assume its neutral.  Fraser has always better on Culterelle, and this could well be the mechanism, raising IFN-gamma in the brain!  He has only one per day, but considering a new packet arrived at my door on Friday, i’m going to up his dose and see what happens.  I won’t be expecting a miracle (not that I would knock one back), but, how can I not give it a go?

It is so reassuring to see articles like this coming up, and to know that behind closed lab doors all over the world, people are working to solve these big puzzles. I am grateful to the scientists, the nutritionists and of course, the little party mice for this invaluable leap forward.  Keep up the good work dudes!

Lots of love,

Kitty xx

 

 

 

Probiotics for Histamine

Probiotics are an essential tool in your Autism arsenal. Most, if not all Autistic children, have digestive issues, and allergies/sensitivities. If you’ve been researching it for a while, you’ve probably come to the conclusion, like a lot of us, that Autism is a gut, not a brain disorder.  What is little known, is that there is a second brain in the gut.  It produces neurotransmitters, just like the one upstairs.  Now, i’m not saying that there aren’t things going wrong in the upstairs brain, but we need to fix the ‘gutbrain’ first.  When you think about a drunk person you can get your head around it.  Are they walking funny, and talking loud and slurring their words  because of something that has happened to their brain?  Yes, they are, but it didn’t start in the brain.  The behaviour is a direct result of something they put in their mouth, that went through the liver and digestive system, then altered the way the brain perceives the world around it and the way they behave.  The input altered the output.  If you use that analogy with Autism, you can see why it’s so important to fix the gut first.

So probiotic basics.  There are many different strains of probiotics available and they all do very different things. At the moment, I am treating Fraser for high histamine, so this is my focus at the this point.  Below is a list of different probiotic strains with what they do, and whether or not they raise histamine, lower histamine or are neutral.  If you give a probiotic that raises histamine to a histadelic child, then even with the best of intentions, you are going to make it worse.

Before I give you the info, I must make the point, that giving probiotics should not be taken lightly.  You must start slowly and build up slowly over time.  Children, especially Autistic children are very sensitive, and you can cause major die off symptoms such as eczema, rashes, diarrhoea, vomiting and flu like symptoms, so slow and steady dear friends!

HISTAMINE LOWERING PROBIOTICS

L. Plantarum 

Produces natural antibiotic Lactolin, synthesizes L-lysine which is antiviral. Can preserve nutrients, vitamins and antioxidants. Eliminate toxins, including S.aureus (golden staff) from foods.

B. Infantis

Stimulates production of immunomodulating agents such as cytokines. Bacteriocidal activity in Clostridia, Salmonella and Shigella.

B. Longum

Plays a role in preventing colonization of invading pathogenic bacteria by attaching to the intestinal wall and crowding out unfriendly bacteria and yeast. Produces lactic and acetic acids to lower the intestinal pH and inhibit undesirable bacteria. Reduces gastro issues from antibiotics.

HISTAMINE NEUTRAL PROBIOTICS

L. Acidophilus

Natural antibiotic, enhance immunity, antimicrobial against strep, s. aureus, salmonella, E. coli and candida albicans.

L. Rhamnosus

Helpful in preventing Urinary Tract Infections, protects agains strep and clostridia. Helpful for those with lactose intolerance. Down regulates hypersensitive reactions and intestinal inflammation in people with eczema and food sensitivities

 

HISTAMINE RAISING PROBIOTICS

L. Bulgaricus

L. Casei

L. Reuteri

There are many other probiotics and I know Culterelle  is a very popular probiotic, but after much searching I am unable to determine at this stage if it, or other strains are raising, lowering or neutral. I will of course keep searching.

The products I am using at the moment are :

Jarrow Formulas – Ideal Bowel Support.  Gluten free L. Plantarum 10 billion live organisms.  From iherb. Use my code FUR941 for a discount on your order.

Nutrition Care – Lactobac.    B. Longum 750 million organisms and L. Rhamnosus 14.25 billion organisms. (Must be posted and kept refrigerated, so leave an esky at your front door with a note for the postman if you’re not going to be home). From Kingsway Compounding Pharmacy in Sydney.

I truly hope this helps someone out there. For my part, I feel great getting it out of my head and onto a blog where it might do somebody some good.

Good luck on your own quest, and i’ll keep you posted 🙂

Kitty. xx

Link to my app – https://itunes.apple.com/au/app/emotion-fonts/id779305002?mt=8